Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries
J. appl. oral sci
;
18(2): 166-170, Mar.-Apr. 2010. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-550408
ABSTRACT
OBJECTIVE: The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL AND METHODS: A convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT>1). DNA was obtained from a mouthwash with 3 percent glucose solution, followed by a scrapping of the oral mucosa. After DNA purification, polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1. RESULTS: Allele 1 of the study polymorphism was associated with low DMFT index and showed a protective effect against caries experience (OR=0.16, IC=0.03-0.76, p=0.01). CONCLUSIONS: Lactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Caries Dental
/
Susceptibilidad a Caries Dentarias
/
Lactoferrina
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Pontifical Catholic University of Paraná/BR
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