The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis
Braz. j. med. biol. res
;
43(7): 619-626, July 2010. ilus
Artículo
en Inglés
| LILACS
| ID: lil-550741
ABSTRACT
Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
ARN Neoplásico
/
Biomarcadores de Tumor
/
Regulación Leucémica de la Expresión Génica
/
MicroARNs
/
Leucemia-Linfoma Linfoblástico de Células T Precursoras
/
Hematopoyesis
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS