Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients
Mem. Inst. Oswaldo Cruz
;
105(4): 370-373, July 2010. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-554799
ABSTRACT
In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80 percent) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Apirasa
/
Schistosoma mansoni
/
Esquistosomiasis mansoni
/
Solanum tuberosum
/
Inmunoglobulina G
/
Anticuerpos Antihelmínticos
Tipo de estudio:
Estudio diagnóstico
Límite:
Aged80
/
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto de Pesquisas René Rachou-Fiocruz/BR
/
Universidade Federal de Juiz de Fora/BR
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