Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application: [review]
Int. braz. j. urol
;
36(3): 273-282, May-June 2010.
Artículo
en Inglés
| LILACS
| ID: lil-555186
ABSTRACT
Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Receptores de Factores de Crecimiento de Fibroblastos
/
Factor A de Crecimiento Endotelial Vascular
/
Receptores ErbB
Límite:
Humanos
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
University of Colorado Denver/US
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