Recovery of hormone sensitivity after salvage brachytherapy for hormone refractory localized prostate cancer
Int. braz. j. urol
;
36(3): 283-291, May-June 2010. graf
Artículo
en Inglés
| LILACS
| ID: lil-555187
ABSTRACT
PURPOSE:
Recent work has demonstrated the return of hormone sensitivity after palliative chemotherapy in androgen independent prostate cancer. We wished to establish whether a similar phenomenon existed in patients with no exposure to chemotherapy. MATERIALS ANDMETHODS:
A review of hormone resistant patients who had received salvage brachytherapy for localized prostate cancer after previous external beam radiotherapy was undertaken. Three patients with subsequent biochemical relapse responded to the rechallenge with hormonal treatment.RESULTS:
The series of patients presented here demonstrates this phenomenon occurs after salvage brachytherapy with no exposure to chemotherapy. Recovery of sensitivity is demonstrated both to androgen deprivation and to androgen receptor antagonism. The recovery of hormone sensitivity was surprisingly durable, ranging from eight months to over twenty-one months.CONCLUSIONS:
Hormone sensitivity may be recovered after salvage brachytherapy. Potential mechanisms underlying these observations are discussed and the likely central role of the activity of the androgen receptor highlighted. The relevance of these findings to the management of advanced prostate cancer is considered including thoughts on the practice of intermittent anti-androgen therapy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias de la Próstata
/
Braquiterapia
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Estudio diagnóstico
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Reino Unido
Institución/País de afiliación:
St Bartholomew's Hospital/GB
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