Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection
Braz. j. infect. dis
;
14(3): 252-255, May-June 2010. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-556837
ABSTRACT
BACKGROUND:
Fever as a common presenting complaint in pediatric patients can be due to various causes. Differentiating bacterial infection from other causes is important because the prompt use of antibiotics is critical in bacterial infection. Traditional markers of infection such as BT and WBC count may be unspecific and culture may be late or absent. CRP and Procalcitonin (PCT) have been considered to evaluate the evolution of infections and sepsis in patients presenting with SIRS. Neopterin has also been proposed to aid in the diagnosis of bacterial infection. In this study, we compared the value of the serum PCT, neopterin level, and WBC count for predicting bacterial infection and outcome in children with fever.METHODS:
158 pediatric (2-120-month-old) patients suspected to have acute bacterial infection, based on clinical judgment in which other causes of SIRS were ruled out were included in the study. WBC count with differential was determined and PCT and neopterin levels were measured.RESULTS:
PCT level was higher in bacterial infection and patients who were complicated or expired.CONCLUSION:
Rapid PCT test is superior to neopterin and WBC count for anticipating bacterial infection, especially in ED where prompt decision making is critical. ABBREVIATIONS BT, body temperature; WBC, white blood cell; PCT, procalcitonin; CRP, C-reactive protein; SIRS, systemic inflammatory response syndrome; ED, emergency department.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Precursores de Proteínas
/
Infecciones Bacterianas
/
Calcitonina
/
Síndrome de Respuesta Inflamatoria Sistémica
/
Neopterin
Límite:
Niño
/
Child, preschool
/
Humanos
/
Lactante
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Baghiatallah University of Medical Sciences/IR
/
Sanandaj University of Medical Sciences/IR
/
Tabriz University of Medical Sciences/IR
/
Tehran University of Medical Sciences/IR
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