Acute HIV infection with rapid progression to AIDS
Braz. j. infect. dis
;
14(3): 291-293, May-June 2010. ilus
Artículo
en Inglés
| LILACS
| ID: lil-556844
ABSTRACT
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neumonía por Pneumocystis
/
Infecciones Oportunistas Relacionadas con el SIDA
/
Progresión de la Enfermedad
/
Fármacos Anti-VIH
/
Pneumocystis carinii
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Faculdade de Medicina de São Paulo/BR
/
Massachusetts General Hospital/US
/
Universidade Federal da Bahia/BR
/
Wisconsin National Primate Research/US
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