Methemoglobinemia and dapsone levels in patients with leprosy
Braz. j. infect. dis
;
14(3): 319-321, May-June 2010.
Artículo
en Inglés
| LILACS
| ID: lil-556850
ABSTRACT
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191 percent, and in female was 2.84 ± 1.67 percent. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dapsona
/
Lepra Multibacilar
/
Leprostáticos
/
Metahemoglobinemia
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Pará/BR
Similares
MEDLINE
...
LILACS
LIS