Frecuencia de anticuerpos para 14 serovariedades de Leptospira spp detectados por la prueba de microaglutinación en una serie de casos humanos de Antioquia, Colombia / Frequency of antibodies against 14 serovars of Leptospira spp detected by microagglutination in human cases from Antioquia, Colombia

RESUMEN

La leptospirosis es una zoonosis de gran incidencia en regiones tropicales debido a factores ambientales, climáticos y sociales que favorecen su transmisión. La microaglutinación (MAT) es la prueba diagnóstica de referencia para la Organización Mundial de la Salud, la prueba se emplea además para estudios epidemiológicos por ser una prueba serovar específica, es decir, que puede precisar las serovariedades que están circulando en poblaciones humanas y animales, dato indispensable cuando se plantea establecer las bases para proponer medidas de control de la enfermedad. Se propuso determinar la frecuencia de anticuerpos para 14 serovariedades de Leptospira...

ABSTRACT

Leptospirosis is a zoonotic disesase of great incidence intropical regions due to environmental, climatic and social factors that favor its transmission. The microagglutinationtest (MAT) is the reference diagnostic for the World Organization of the Health, test is also used for epidemic studies to be a test serovar specific, it can specify these rovars that are circulating in human and animal populations, indispensable fact when is necessary to establish the bases to propose measures of control of the illness. To determine the frequency of antibodies for 14 serovars of Leptospira spp in 49 individuals that consulted to the Colombian Institute of Tropical Medicine-CES, during the period of 2000-2006, to confirm the leptospirosis diagnosis. The 49 individuals had an age 34.2 year-old average, 53,8 % was men. 70 % was residents in the Medellin city and other Antioquia municipalities, of which 30 % came from Apartado in the region North West of Antioquia state. The MAT revealed that 67,34 % of the serums agglutinated with the serovar Grippotyphosa; 63,2 % for the serovar Copenhageni; 40,81 % belonged to the serovar Icterohaemorragiae; 6,12 % for the serovar Tarassovi and 2,04 % presented agglutinations against L. biflexa. This study allowed the presence of Leptospira and the serovars that are infecting the population from Antioquia state and it demonstrates that there are several circulating serovars.