Hepatitis C in hemodialysis: the contribution of injection drug use
Braz. j. infect. dis
; 14(4): 422-426, July-Aug. 2010. tab
Article
en En
| LILACS
| ID: lil-561219
Biblioteca responsable:
BR1.1
ABSTRACT
BACKGROUND:
Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD.METHODS:
This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV), and qualitative polymerase chain reaction (PCR).RESULTS:
Of 325 patients, 68 had positive HCV RNA results. The comparison between patients with positive and negative PCR results revealed significant differences in duration of HD (mean = 71 versus 52.4 months; p = 0.02); previous blood transfusion (92 percent versus 72 percent; p < 0.01); injection drug use (13 percent versus 0.7 percent; p < 0.01); anti-HCV positivity at start of HD therapy (60 percent versus 4 percent; p < 0.01); and mean ALT value (39 versus 26.5; p < 0.01). Logistic regression analysis showed a positive HCV RNA independently associated to being on HD for more than five years [OR 2.1 (95 percent CI 1.2 -3.8)]; previous blood transfusion [OR 3.7 (95 percent CI 1.4 - 9.5)]; and injection drug use [OR 22.6 (95 percent CI 4.2 - 119.6)].CONCLUSION:
Injection drug use was an independent risk factor for HCV infection among chronic renal disease patients on HD.Palabras clave
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Índice:
LILACS
Asunto principal:
ARN Viral
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Diálisis Renal
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Hepatitis C
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Anticuerpos contra la Hepatitis C
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Trastornos Relacionados con Sustancias
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Alanina Transaminasa
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Qualitative_research
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz. j. infect. dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2010
Tipo del documento:
Article