Formulation and evaluation of glipizide floating-bioadhesive tablets
Braz. arch. biol. technol
;
53(5): 1073-1085, Sept.-Oct. 2010. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-564083
ABSTRACT
The purpose of this study was formulation and in vitro evaluation of floating-bioadhesive tablets to lengthen the stay of glipizide in its absorption area. Effervescent tablets were made using chitosan (CH), hydroxypropyl methylcellulose (HPMC), carbopolP934 (CP), polymethacrylic acid (PMA), citric acid, and sodium bicarbonate. Tablets with 5 percent effervescent base had longer lag time than 10 percent. The type of polymer had no significant effect on the floating lag time. All tablets floated atop the medium for 23-24 hr. Increasing carbopolP934 caused higher bioadhesion than chitosan (p < 0.05). All formulations showed a Higuchi, non-Fickian release mechanism. Tablets with 10 percent effervescent base, 80 percent CH/20 percent HPMC, or 80 percent CP/20 percent PMA seemed desirable.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
Braz. arch. biol. technol
Asunto de la revista:
Biologia
Año:
2010
Tipo del documento:
Artículo
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