Marcadores genéticos en hipertensión esencial / Genetic markers in essential hypertension
Rev. méd. Chile
; 138(6): 767-772, jun. 2010. tab
Article
en Es
| LILACS
| ID: lil-567574
Biblioteca responsable:
CL1.1
ABSTRACT
Essential hypertension (HTA) is a multifactorial disease and in Chile, its prevalence is 33.7 percent. There is a genetic predisposition to develop hypertension, whose magnitude is approximately 30 to 50 percent. At present, some factors are known to increase the risk for cardiovascular disease, but widely accepted biomarkers for screening are missing. The frst studies that looked for candidate genes have focused on the reninangiotensin - aldosterone, aducina, adrenoreceptors ß, G protein subunits, G protein signaling regulators, kinases associated with G proteins and Rho kinases. Studies of DNA sequencing, search for polymorphisms and variants through single nucleotide polymorphisms, have been used to seek partnerships with complex or multifactorial diseases, like HTA. Examples of these are components of collagen proteins, genes related to cell myocardial proteins belonging to cytochrome P450 and growth factors, among others. It is still unlikely to count in a near future with a universal marker. Most probably, a series of markers that confer susceptibility to a specifc individual will have to be used in prevention programs or personalized therapy.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Sistema Renina-Angiotensina
/
Hipertensión
Tipo de estudio:
Health_technology_assessment
/
Risk_factors_studies
Límite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2010
Tipo del documento:
Article