Función del retículo sarcoplásmico y su papel en las enfermedades cardíacas / Function and role of the sarcoplasmic reticulum in heart disease
Arch. cardiol. Méx
;
76(supl.4): S18-S32, oct.-dic. 2006.
Artículo
en Español
| LILACS
| ID: lil-568135
ABSTRACT
The sarcoplasmic reticulum (SR) constitutes the main intracellular calcium store in striated muscle and plays an important role in the regulation of excitation-contraction-coupling (ECC) and of intracellular calcium concentrations during contraction and relaxation. The regulation of ECC occurs due to the interaction among the main proteins of the SR that are the calcium release channel or ryanodine receptor, the Ca2+-ATPase, phospholamban and calsequestrin. Due to the importance of ECC in the physiopathology of a number of cardiac diseases, the role of the SR and its components has been widely investigated in some pathologies, specifically cardiac hypertrophy, heart failure, and hereditary arrhythmias. Therefore, the SR proteins constitute an area of research of great interest for the development of new genetic and pharmacologic therapies; from this derives the importance of understanding the function of the SR. This review analyzes the expression, structure, and function of the main SR proteins, their role on myocardial contraction and relaxation and in the changes that occur in cardiac pathologies.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Retículo Sarcoplasmático
/
Cardiopatías
/
Contracción Miocárdica
Límite:
Humanos
Idioma:
Español
Revista:
Arch. cardiol. Méx
Asunto de la revista:
Cardiología
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
UNAM/MX
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