Deficiencia de vitamina D: ¿Factor de riesgo de síndrome metabólico? / Association between vitamin D deficiency and metabolic syndrome
Rev. méd. Chile
;
138(10): 1312-1318, oct. 2010. ilus
Artículo
en Español
| LILACS
| ID: lil-572946
ABSTRACT
Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Deficiencia de Vitamina D
/
Síndrome Metabólico
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Venezuela
Institución/País de afiliación:
Universidad de Carabobo/VE
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