Assessment of the genetic risks of a metallic alloy used in medical implants
Genet. mol. biol
;
34(1): 116-121, 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-573718
ABSTRACT
The use of artificial implants provides a palliative or permanent solution for individuals who have lost some bodily function through disease, an accident or natural wear. This functional loss can be compensated for by the use of medical devices produced from special biomaterials. Titanium alloy (Ti-6Al-4V) is a well-established primary metallic biomaterial for orthopedic implants, but the toxicity of the chemical components of this alloy has become an issue of concern. In this work, we used the MTT assay and micronucleus assay to examine the cytotoxicity and genotoxicity, respectively, of an extract obtained from this alloy. The MTT assay indicated that the mitochondrial activity and cell viability of CHO-K1 cells were unaffected by exposure to the extract. However, the micronucleus assay revealed DNA damage and an increase in micronucleus frequency at all of the concentrations tested. These results show that ions released from Ti-6Al-4V alloy can cause DNA and nuclear damage and reinforce the importance of assessing the safety of metallic medical devices constructed from biomaterials.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Materiales Biocompatibles
/
Pruebas de Micronúcleos
/
Citotoxicidad Inmunológica
/
Pruebas de Mutagenicidad
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de São João Del Rei/BR
/
Universidade do Vale do Paraíba/BR
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