Effects of Urtica dioica on hepatic ischemia-reperfusion injury in rats
Clinics
;
65(12): 1357-1361, 2010. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-578577
ABSTRACT
OBJECTIVES:
To evaluate the effects of Urtica dioica on hepatic ischemia-reperfusion injury.METHODS:
Thirty adult male Wistar albino rats were divided into three groups sham group (group 1), control group (group 2), and Urtica dioica group (group 3). All the rats were exposed to hepatic ischemia for 60 min, followed by 60 min of reperfusion. In group 2, a total of 2 ml/kg 0.9 percent saline solution was given intraperitoneally. In group 3, a total of 2 ml/kg Urtica dioica was given intraperitoneally. At the end of the procedure, liver tissue and blood samples were taken from all rats. Serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ceruloplasmin, catalase, paraoxonase, arylesterase, and lipid hydroperoxide levels were measured. Liver tissue histopathologies were also evaluated by light microscopy.RESULTS:
Serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were significantly higher in group 2 than in group 1, and significantly lower in group 3 than in group 2. Also, group 2 had higher serum lipid hydroperoxides and ceruloplasmin levels but lower catalase, paraoxonase, and arylesterase levels than group 1. In group 3, serum lipid hydroperoxides and ceruloplasmin levels were significantly lower, and catalase, paraoxonase, and arylesterase levels were higher than those in group 2. Histopathological examination showed that liver tissue damage was significantly decreased in group 3 compared with group 2.CONCLUSIONS:
Urtica dioica has a protective effect on the liver in hepatic ischemia-reperfusion-injured rats.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Extractos Vegetales
/
Daño por Reperfusión
/
Urtica dioica
/
Hígado
/
Fitoterapia
Tipo de estudio:
Revisiones Sistemáticas Evaluadas
Límite:
Animales
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Duzce University/TR
/
State Hospital/TR
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