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Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
Rodrigues, Moacyr Tadeu Vicente; Cardoso, Camila Lopes; Carvalho, Paulo Sérgio Perri de; Cestari, Tânia Mary; Feres, Magda; Garlet, Gustavo Pompermaier; Ferreira Júnior, Osny.
  • Rodrigues, Moacyr Tadeu Vicente; São Lucas School. Porto Velho. BR
  • Cardoso, Camila Lopes; University of São Paulo. Bauru School of Dentistry. Department of Stomatology. Bauru. BR
  • Carvalho, Paulo Sérgio Perri de; University of São Paulo. Bauru School of Dentistry. Department of Stomatology. Bauru. BR
  • Cestari, Tânia Mary; University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Feres, Magda; Guarulhos University. Dental Research Division. Guarulhos. BR
  • Garlet, Gustavo Pompermaier; University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Ferreira Júnior, Osny; University of São Paulo. Bauru School of Dentistry. Department of Stomatology. Bauru. BR
J. appl. oral sci ; 19(3): 260-268, May-June 2011. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-588133
ABSTRACT
The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed.

OBJECTIVE:

In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs. MATERIAL AND

METHODS:

Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis.

RESULTS:

All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone).

CONCLUSION:

These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Extracción Dental / Cicatrización de Heridas / Alveolo Dental / Alveolo Seco Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Guarulhos University/BR / São Lucas School/BR / University of São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Extracción Dental / Cicatrización de Heridas / Alveolo Dental / Alveolo Seco Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Guarulhos University/BR / São Lucas School/BR / University of São Paulo/BR