Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
Mem. Inst. Oswaldo Cruz
;
106(3): 285-292, May 2011. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-589036
ABSTRACT
Brevidensoviruses have an encapsidated, single-stranded DNA genome that predominantly has a negative polarity. In recent years, they have received particular attention due to their potential role in the biological control of pathogenic arboviruses and to their unnoticed presence in cell cultures as contaminants. In addition, brevidensoviruses may also be useful as viral vectors. This study describes the first genetic and biological characterization of a mosquito densovirus that was isolated in Brazil; moreover, we examined the phylogenetic relationship between this isolate and the other brevidensoviruses. We further demonstrate that this densovirus has the potential to be used to biologically control dengue virus (DENV) infection with in vitro co-infection experiments. The present study provides evidence that this densovirus isolate is a fast-spreading virus that affects cell growth and DENV infection.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Densovirus
/
Virus del Dengue
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Instituto Carlos Chagas-Fiocruz/BR
/
Mississippi State University/US
/
Universidade Federal do Rio de Janeiro/BR
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