Benznidazole levels in blood vary with age in rats
Mem. Inst. Oswaldo Cruz
;
106(3): 374-377, May 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-589051
ABSTRACT
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tripanocidas
/
Microsomas Hepáticos
/
Cromatografía Líquida de Alta Presión
/
Nitroimidazoles
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Institute of Scientific and Technological Research of the Armed Forces/AR
Similares
MEDLINE
...
LILACS
LIS