Candida species isolated from the vaginal mucosa of HIV-infected women in Salvador, Bahia, Brazil
Braz. j. infect. dis
;
15(3): 239-244, May-June 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-589955
ABSTRACT
BACKGROUND:
Vulvovaginal candidiasis (VVC) is the second most common vaginal infection. HIV-infection is a risk factor for this infection.OBJECTIVE:
To determine the frequency of VVC and to describe the main Candida species isolated and their susceptibility to antifungal drugs in HIV-infected patients, compared to HIV-uninfected women in Salvador, Brazil.METHODS:
Cross-sectional study including a group of 64 HIV-infected women and 76 uninfected women, followed up at the AIDS reference center and at the Gynecological Clinic of Escola Bahiana de Medicina e Saúde Pública (Salvador, Bahia, Brazil).RESULTS:
Frequency of Candida spp. was higher in HIV-infected women (29.7 percent) than in HIV-uninfected controls (14.5 percent) (p = 0.02). The odds ratio value for vulvovaginal candidiasis in HIV-infected patients was 2.6 (95 percent CI 1.07 - 6.32 p = 0.03). Candida albicans was the most commonly isolated species in both HIV-infected (52.3 percent) and uninfected women (85.7 percent), followed by C. parapsolis in 17.6 percent and 14.3 percent, respectively. In HIV-infected women, C. glabrata, C. parapsilosis, and a coinfection of C. albicans and C. glabrata were also identified. There was no significant difference between Candida species isolated from the vaginal mucosa of women with VVC and colonization of the vaginal mucosa of HIV-infected and HIV-uninfected women. One C. glabrata isolate from an HIV-infected patient was resistant to fluconazole and other two isolates exhibited a dose-dependent susceptibility.CONCLUSION:
Our results confirm a higher frequency of Candida spp. isolated from the vaginal mucosa of HIV-infected women and a broader spectrum of species involved. Only Candida glabrata isolates showed decreased susceptibility to fluconazole.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Candida
/
Candidiasis Vulvovaginal
/
Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Francia
Institución/País de afiliación:
EBMSP/BR
/
Escola Bahiana de Medicina e Saúde Pública/BR
/
FIOCRUZ/BR
/
Laboratoire de Mycologie-Parasitologie/FR
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