Your browser doesn't support javascript.
loading
Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?
Oliveira, Luiz Carlos Marques de; Comácio, Samantha Martins; Santos, Júlia de Fátima Gonçalves.
  • Oliveira, Luiz Carlos Marques de; Universidade Federal de Uberlândia. Medical School. Department of Internal Medicine. BR
  • Comácio, Samantha Martins; Universidade Federal de Uberlândia. Medical School. BR
  • Santos, Júlia de Fátima Gonçalves; Universidade Federal de Uberândia. Hospital de Clínicas. Gastroenterology Service.
Braz. j. infect. dis ; 15(3): 268-271, May-June 2011. tab
Artículo en Inglés | LILACS | ID: lil-589960
ABSTRACT

BACKGROUND:

Patients with chronic liver disease have a higher risk of fulminant hepatitis when infected with hepatitis A virus, and vaccination of these patients against such infection is recommended. In Brazil, mainly in the South and Southeast regions, the epidemiology of hepatitis A (HA) has shifted from high to intermediate endemicity, which would have implication on policy of HA vaccination for these populations.

OBJECTIVE:

To verify the prevalence of HA immunity in adult patients with liver cirrhosis (LC), in Uberlândia MG, a city of Southeastern Brazil.

METHODS:

Between December 2005 and December 2006, 106 patients with LC were consecutively evaluated. In addition, 75 individuals without LC or alcoholism were evaluated (control group - CG).

RESULTS:

Total anti-HAV (ELISA methods) was positive in 104 (98.1 percent) patients with LC (82 men, 24 women; mean age, 53.3 ± 11.9 years) and in 74 (98.7 percent) individuals of the CG (55 men, 20 women; mean age, 47 ± 11.6 years), p > 0.05.

CONCLUSIONS:

For patients with chronic liver disease, in the geographic regions and age groups evaluated, routine vaccination against hepatitis A is not recommended. Moreover, the serum determination of total anti-HAV, used to assess immunity, is five times cheaper than vaccination against hepatitis A and, for this reason, should precede vaccination.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Virus de la Hepatitis A / Hepatitis A / Cirrosis Hepática Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Uberlândia/BR

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Virus de la Hepatitis A / Hepatitis A / Cirrosis Hepática Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Uberlândia/BR