Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Biol. Res
;
44(1): 17-23, 2011. ilus
Artículo
en Inglés
| LILACS
| ID: lil-591860
ABSTRACT
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Permeabilidad de la Membrana Celular
/
Dendritas
/
Retículo Endoplásmico
/
Proteínas de la Membrana
/
Plasticidad Neuronal
Límite:
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2011
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
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