Regulation of cell polarity by controlled proteolytic systems
Biol. Res
;
44(1): 35-41, 2011. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-591862
ABSTRACT
Epithelial and neuronal cells are highly asymmetric, with discrete regions responsible for different roles that underlie the generation of specific compartments within cells that are distinct in biochemical composition, structure, and morphology that ultimately lead to distinct functions. Controlled and specific molecular targeting and sorting have been studied to understand the generation of asymmetric domains inside cells. Recently, a new and complementary explanation has emerged to account for the generation of domains that are enriched by a subset of proteins or polarization determinants local proteolysis. In this review, we discuss the most conspicuous proteolytic systems that may contribute to the generation of cell polarity, namely the ubiquitin-proteosome and the calpain systems. Specifically, we focus this review on two cellular processes that depend on the acquisition of cell polarity; cell migration and the establishment of an axon in a neuronal cell.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Calpaína
/
Polaridad Celular
/
Ubiquitina
/
Complejo de la Endopetidasa Proteasomal
/
Proteolisis
/
Neuronas
Límite:
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2011
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
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