Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
Mem. Inst. Oswaldo Cruz
;
106(4): 507-509, June 2011. graf
Artículo
en Inglés
| LILACS
| ID: lil-592197
ABSTRACT
In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes. Miltefosine induced a process of programmed cell death, which was determined by the externalization of phosphatidylserine, the incorporation of propidium iodide, cell-cycle arrest at the sub-G0/G1 phase and DNA fragmentation into oligonucleosome-sized fragments. Despite the intrinsic variation that is detected in Leishmania spp, our results indicate that miltefosine causes apoptosis-like death in L. amazonensis promastigote cells using a similar process that is observed in Leishmania donovani.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Fosforilcolina
/
Leishmania mexicana
/
ADN Protozoario
/
Apoptosis
/
Fragmentación del ADN
/
Antiprotozoarios
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fiocruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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