The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
Clinics
;
66(5): 743-746, 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-593834
ABSTRACT
OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration. RESULT: The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05). CONCLUSION: The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Superóxido Dismutasa
/
Peroxidación de Lípido
/
Estrés Oxidativo
/
Neovascularización Coroidal
/
Glutatión Peroxidasa
/
Degeneración Macular
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Ankara Numune Education and Research Hospital/TR
/
Duatepe Government Hospita/TR
/
Etimesgut Public Health Laboratory/TR
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