Urban, traffic- related particles and lung tumors in urethane treated mice
Clinics
; 66(6): 1051-1054, 2011. ilus, graf
Article
en En
| LILACS
| ID: lil-594377
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVE:
The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions.METHODS:
Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted.RESULTS:
Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure.CONCLUSION:
Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Contaminantes Atmosféricos
/
Neoplasias Pulmonares
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Clinics
Asunto de la revista:
MEDICINA
Año:
2011
Tipo del documento:
Article