Urban, traffic- related particles and lung tumors in urethane treated mice
Clinics
;
66(6): 1051-1054, 2011. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-594377
ABSTRACT
OBJECTIVE:
The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions.METHODS:
Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted.RESULTS:
Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure.CONCLUSION:
Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Contaminantes Atmosféricos
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
/
University of São Paulo/BR
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