Involvement of nitric oxide pathways in neurogenic pulmonary edema induced by vagotomy
Clinics
;
66(6): 1061-1066, 2011. graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-594379
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the involvement of peripheral nitric oxide (NO) in vagotomy-induced pulmonary edema by verifying whether the nitric oxide synthases (NOS), constitutive (cNOS) and inducible (iNOS), participate in this mechanism.INTRODUCTION:
It has been proposed that vagotomy induces neurogenic pulmonary edema or intensifies the edema of other etiologies.METHODS:
Control and vagotomized rats were pretreated with 0.3 mg/kg, 3.0 mg/kg or 39.0 mg/kg of L-NAME, or with 5.0 mg/kg, 10.0 mg/kg or 20.0 mg/kg of aminoguanidine. All animals were observed for 120 minutes. After the animals' death, the trachea was catheterized in order to observe tracheal fluid and to classify the severity of pulmonary edema. The lungs were removed and weighed to evaluate pulmonary weight gain and edema index.RESULTS:
Vagotomy promoted pulmonary edema as edema was significantly higher than in the control. This effect was modified by treatment with L-NAME. The highest dose, 39.0 mg/kg, reduced the edema and prolonged the survival of the animals, while at the lowest dose, 0.3 mg/kg, the edema and reduced survival rates were maintained. Aminoguanidine, regardless of the dose inhibited the development of the edema. Its effect was similar to that observed when the highest dose of L-NAME was administered. It may be that the non-selective blockade of cNOS by the highest dose of L-NAME also inhibited the iNOS pathway.CONCLUSION:
Our data suggest that iNOS could be directly involved in pulmonary edema induced by vagotomy and cNOS appears to participate as a protector mechanism.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Edema Pulmonar
/
Vagotomía
/
Óxido Nítrico Sintasa de Tipo II
/
Óxido Nítrico Sintasa de Tipo III
/
Óxido Nítrico
Tipo de estudio:
Estudio de etiología
/
Estudios de evaluación
Límite:
Animales
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of São Paulo/BR
/
Universidade Estadual de Londrina/BR
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