CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Biocell
;
34(2): 91-94, Aug. 2010. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-595038
ABSTRACT
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Leucemia Mieloide
/
Movimiento Celular
/
Extensiones de la Superficie Celular
Límite:
Humanos
Idioma:
Inglés
Revista:
Biocell
Asunto de la revista:
Clulas
Año:
2010
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
China Medical University/CN
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