In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals
Braz. oral res
;
25(1): 28-33, Jan.-Feb. 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-595842
ABSTRACT
Oropharyngeal candidiasis is the most common fungal infection among HIV-positive patients. This condition can be treated with either systemic or topical antifungal agents; treatments are usually indicated empirically on the basis of clinical data. The knowledge of in vitro antifungal susceptibility is important to determine correct therapeutic guides for the treatment of fungal infections. Therefore, the objective of this study was to determine the antifungal susceptibility profile of oral Candida isolates from HIV-positive patients and control individuals. Amphotericin B, fluconazole, flucytosine, nystatin and ketoconazole were tested according to the methodology of microdilution proposed by the Clinical and Laboratory Standards Institute (CLSI); results were recorded in values of minimal inhibitory concentration (MIC). A total of 71 Candida isolates from HIV-positive patients were examined with the following species represented C. albicans (59), C. tropicalis (9), C. glabrata (1), C. guilliermondii (1) and C. krusei (1). A total of 15 Candida isolates were evaluated from control individuals comprised of 11 C. albicans and 4 C. tropicalis samples. Our results demonstrated that the tested antifungal agents showed good activity for most isolates from both groups; however, variability in MIC values among isolates was observed.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Candida
/
Infecciones por VIH
/
Farmacorresistencia Fúngica Múltiple
/
Antifúngicos
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. oral res
Asunto de la revista:
Odontología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Univ Estadual Paulista/BR
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