Oncological and functional outcomes following open radical prostatectomy: how patients may achieve the "trifecta"?
Int. braz. j. urol
;
37(3): 320-327, May-June 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-596006
ABSTRACT
PURPOSE:
The desirable outcomes after open radical prostatectomy (RP) for localized prostate cancer (PC) are to a) achieve disease recurrence free, b) urinary continence (UC), and c) maintain sexual potency (SP). These 3 combined desirable outcomes we called it the "Trifecta". Our aim is to assess the likelihood of achieving the Trifecta, and to analyze the influencing the Trifecta . MATERIALS ANDMETHODS:
A total of 1738 men with localized PC underwent RP from 1992-2007 by a single surgeon. The exclusion criteria for this analysis were preoperative hormonal or radiation therapy, preoperative urinary incontinence or erectile dysfunction, follow-up less than 24 months or insufficient data. Post-operative Trifecta factors were analyzed, including biochemical recurrence (BR).. We defined BR as PSA > 0.2 ng/mL, urinary continence as wearing no pads, and sexual potency as having erections sufficient for intercourse with or without a phosphodiesterase-5 inhibitor.RESULTS:
A total of 831 patients met the inclusion criteria. The mean age of the entire cohort was 59 years old. The median follow-up was 52 months (mean 60, range 24-202). The BR, UC and SP rates were 18.7 percent, 94.5 percent, and 71 percent respectively. Trifecta was achieved in 64 percent at 2 year follow-up, and 61 percent at 5 year follow-up. Multivariate analysis revealed age at time of surgery, pathologic Gleason score (PGS), pathologic stage, specimen weight, and nerve sparing (NS) were independent factors.CONCLUSIONS:
Age at time of surgery, pathologic GS, pathologic stage, specimen weight and NS were independent predictors to achieve the Trifecta following radical prostatectomy. This information may help patients counseling undergoing radical prostatectomy for localized prostate cancer.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Prostatectomía
/
Neoplasias de la Próstata
/
Incontinencia Urinaria
/
Disfunción Eréctil
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
University of Miami/US
Similares
MEDLINE
...
LILACS
LIS