Monitoring of BCR-ABL levels in chronic myeloid leukemia patients treated with imatinib in the chronic phase: the importance of a major molecular response
Rev. bras. hematol. hemoter
;
33(3): 211-215, June 2011. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-596324
ABSTRACT
BACKGROUND:
Real time PCR has become the most common technique to monitor BCR-ABL transcript levels of patients treated with kinase inhibitors. The aim of this study was to evaluate BCR-ABL levels of chronic myeloid leukemia patients treated with imatinib in the chronic phase and correlate the response to therapy and event-free survival.METHODS:
BCR-ABL levels were measured in peripheral blood cell samples using Real time PCR at diagnosis and then every 3 months after starting therapy with imatinib. Major molecular response was defined as a three-log reduction from the standardized baseline value. Major molecular response values were adjusted to international scale using a conversion factor of 1.19. The results are reported as a BCR-ABL/ABL ratio ( percent).RESULTS:
Hematological, major cytogenetic and complete cytogenetic responses were achieved by 57 (95 percent), 45 (75 percent) and 38 (63 percent) patients, respectively. Twenty-four out of sixty patients achieved a major molecular response (40 percent) in a median time of 8.5 months. Overall survival and event free survival were higher for patients with (100 percent) versus patients without (77 percent) a complete cytogenetic response (p-value = 0.01) at 48 months. Patients with complete cytogenetic response and major molecular response had a higher event free survival compared to patients with complete cytogenetic response but without major molecular response (p-value = 0.007).CONCLUSION:
In conclusion, the prognostic impact of achieving complete cytogenetic response and a major molecular response and also the importance of molecular monitoring in the follow-up of chronic myeloid leukemia patients were demonstrated.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Monitoreo del Ambiente
/
Inhibidores de Proteínas Quinasas
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Campinas/BR
/
Universidade Federal do Paraná/BR
/
Universidade de São Paulo/BR
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