Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review
J. venom. anim. toxins incl. trop. dis
;
17(3): 264-270, 2011.
Artículo
en Inglés
| LILACS
| ID: lil-597224
ABSTRACT
Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels in the circulation, as it binds and adsorbs them on the surface of red cells as a reservoir. It plays a "sink" role, which can contribute to homeostasis by removing inflammatory chemokines from circulation as well as maintaining them in plasmatic levels. Chronic Chagas' cardiopathy (CCC) is the most frequent form of the disease. It is an inflammatory disease, in which infiltrated inflammatory cells play an important role in the development and progress of the infection. High chemokine levels in the plasma have been associated with the disease severity in patients with heart failure. In this context, the profile of DARC expression could play an important function as a receptor for chemokines in Chagas' disease, in patients with CCC, as it can modulate damage from this inflammatory disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cardiomiopatía Chagásica
/
Enfermedad de Chagas
/
Receptores de Superficie Celular
/
Quimiocinas
/
Sistema del Grupo Sanguíneo Duffy
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Asunto de la revista:
Toxicología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
São José do Rio Preto School of Medicine/BR
Similares
MEDLINE
...
LILACS
LIS