Your browser doesn't support javascript.
loading
Surface-expressed enolases of Plasmodium and other pathogens
Ghosh, Anil Kumar; Jacobs-Lorena, Marcelo.
  • Ghosh, Anil Kumar; Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore. US
  • Jacobs-Lorena, Marcelo; Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore. US
Mem. Inst. Oswaldo Cruz ; 106(supl.1): 85-90, Aug. 2011. ilus, tab
Artículo en Inglés | LILACS | ID: lil-597248
ABSTRACT
Enolase is the eighth enzyme in the glycolytic pathway, a reaction that generates ATP from phosphoenol pyruvate in cytosolic compartments. Enolase is essential, especially for organisms devoid of the Krebs cycle that depend solely on glycolysis for energy. Interestingly, enolase appears to serve a separate function in some organisms, in that it is also exported to the cell surface via a poorly understood mechanism. In these organisms, surface enolase assists in the invasion of their host cells by binding plasminogen, an abundant plasma protease precursor. Binding is mediated by the interaction between a lysine motif of enolase with Kringle domains of plasminogen. The bound plasminogen is then cleaved by specific proteases to generate active plasmin. Plasmin is a potent serine protease that is thought to function in the degradation of the extracellular matrix surrounding the targeted host cell, thereby facilitating pathogen invasion. Recent work revealed that the malaria parasite Plasmodium also expresses surface enolase, and that this feature may be essential for completion of its life cycle. The therapeutic potential of targeting surface enolases of pathogens is discussed.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Fosfopiruvato Hidratasa / Plasmodium / Membrana Celular Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2011 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Estados Unidos Institución/País de afiliación: Malaria Research Institute/US

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Fosfopiruvato Hidratasa / Plasmodium / Membrana Celular Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2011 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Estados Unidos Institución/País de afiliación: Malaria Research Institute/US