Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal / Hypovitaminosis D in pediatric patients on renal replacement therapy
Rev. méd. Chile
;
139(3): 334-339, mar. 2011. ilus
Artículo
en Español
| LILACS
| ID: lil-597622
ABSTRACT
Background:
Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD).Aim:
To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material andMethods:
Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51 percent females).Results:
Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD 21 ± 16.8, PD 18.9 ± 8.5, Tx 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04).Conclusions:
Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Deficiencia de Vitamina D
/
Terapia de Reemplazo Renal
/
Fallo Renal Crónico
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2011
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
/
Universidad de Chile, Hospital Luis Calvo Mackenna/CL
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