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Plasmodium falciparum gametocyte carriage, emergence, clearance and population sex ratios in anaemic and non-anaemic malarious children
Gbotosho, Grace Olusola; Sowunmi, Akintunde; Okuboyejo, Titilope Modupe; Happi, Christian Tientcha; Michael, Obaro Stanley; Folarin, Onikepe Abiola; Adewoye, Elsie Olufunke.
  • Gbotosho, Grace Olusola; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Sowunmi, Akintunde; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Okuboyejo, Titilope Modupe; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Happi, Christian Tientcha; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Michael, Obaro Stanley; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Folarin, Onikepe Abiola; Institute for Medical Research and Training. Department of Pharmacology and Therapeutics.
  • Adewoye, Elsie Olufunke; University of Ibadan. Department of Physiology. Ibadan. NG
Mem. Inst. Oswaldo Cruz ; 106(5): 562-569, Aug. 2011. graf, tab
Artículo en Inglés | LILACS | ID: lil-597716
ABSTRACT
Anaemia in falciparum malaria is associated with an increased risk of gametocyte carriage, but its effects on transmission have not been extensively evaluated in malarious children. Plasmodium falciparum gametocyte carriage, emergence, clearance, population sex ratios (SR) (defined as the proportion of gametocytes that are male), inbreeding rates and temporal changes in SR were evaluated in 840 malarious children. Gametocyte carriage pre-treatment was at a level of 8.1 percent. Anaemia at enrolment was an independent risk factor for gametocyte carriage post-treatment. The emergence of gametocytes seven days post-treatment was significantly more frequent in anaemic children (7/106 vs. 10/696, p = 0.002). In the initially detected gametocytes, the proportion of children with a male-biased SR (MBSR) (> 0.5) was significantly higher in anaemic children (6/7 vs. 3/10, p = 0.027). Pre-treatment SR and estimated inbreeding rates (proportion of a mother's daughters fertilised by her sons) were similar in anaemic and non-anaemic children. Pre-treatment SR became more female-biased in non-anaemic children following treatment. However, in anaemic children, SR became male-biased. Anaemia was shown to significantly increase gametocyte emergence and may significantly alter the SR of emerging gametocytes. If MBSR is more infective to mosquitoes at low gametocytaemia, then these findings may have significant implications for malaria control efforts in endemic settings where malaria-associated anaemia is common.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Plasmodium falciparum / Malaria Falciparum / Anemia Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Child, preschool / Femenino / Humanos / Masculino Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2011 Tipo del documento: Artículo País de afiliación: Nigeria Institución/País de afiliación: University of Ibadan/NG

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Plasmodium falciparum / Malaria Falciparum / Anemia Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Child, preschool / Femenino / Humanos / Masculino Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2011 Tipo del documento: Artículo País de afiliación: Nigeria Institución/País de afiliación: University of Ibadan/NG