Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
Mem. Inst. Oswaldo Cruz
;
106(5): 617-619, Aug. 2011. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-597723
ABSTRACT
The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Strongyloides
/
Estrongiloidiasis
/
Parasitosis Intestinales
/
Mycobacterium bovis
/
Infecciones por Mycobacterium
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de Minas Gerais/BR
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