The secretory effect of canatoxina ou rat brain synaptosomes involves a lipoxygenase-mediated pathway

Fidalgo, C. Barja; Guimaräes, J. A; Carlini, C. R

Fidalgo, C. Barja; Guimaräes, J. A; Carlini, C. R.

Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;21(3): 549-52, Mar. 1988. ilus

Article en En | LILACS | ID: lil-60248

Biblioteca responsable: BR1.1

RESUMO

RESUMO

Canatoxin (CNTX), a neurotoxic protein, is known to activate platelet secretion and aggregation in vitro through a lipoxygenase-dependent pathway. This study shows that CNTX also induces time and dose-dependent serotonin secretion from rat brain synaptosomes. The secretory effect induced by 6 micronM CNTX was similar to that elicited by 150 mM KCl. Nordihyderoguaiaretic acid (500 micronM) completely abolished CNTX-induced serotonin release while 150 micronM indomethacin had no effect. These data suggest the involvement of the lipoxygenase pathway in neurotransmitter release elicited by CNTX as occurs in the platelet

Asunto(s)

Ratas; Animales; Encéfalo/fisiología; Técnicas In Vitro; Lectinas/farmacología; Masoprocol/farmacología; Serotonina/metabolismo; Sinaptosomas/fisiología; Activación Enzimática/efectos de los fármacos; Lipooxigenasa/metabolismo

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Índice: LILACS Asunto principal: Sinaptosomas / Técnicas In Vitro / Masoprocol / Encéfalo / Serotonina / Lectinas Límite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 1988 Tipo del documento: Article / Congress and conference

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