Portal flow and mitochondrial function during extrahepatic cholestasis
Braz. j. med. biol. res
;
21(3): 637-40, Mar. 1988. tab
Artículo
en Inglés
| LILACS
| ID: lil-60262
ABSTRACT
This study was designed to determine portal blood flow and mitochondrial and hepatic function during extrahepatic obstruction. Twenty-two male Wistar rats which had undergone bile duct ligation were compared 7 days later to 20 sham-operated controls. Portal flow and mitochondrial respiratory control ratio were reduced by 50% and 35%, respectively (P < 0.01), and serum alanine-aminotransferase levels increased significantly (P < 0.01) in the extrahepatic cholestatic group. These results suggest that cholestasis may cause an imbalance between the energy supply and the high demand of the liver leading to a state of partial ischemia
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Índice:
LILACS (Américas)
Asunto principal:
Sistema Porta
/
Colestasis Extrahepática
/
Isquemia
/
Hígado
/
Mitocondrias
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1988
Tipo del documento:
Artículo
/
Congreso y conferencia
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