A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages
Braz. j. med. biol. res
; 21(3): 565-8, Mar. 1988. ilus
Article
en En
| LILACS
| ID: lil-60264
Biblioteca responsable:
BR1.1
ABSTRACT
Rat macrophage monolayers pre-treated with endotoxin release into the incubating fluid a factor (MW >10,000) capable of inducing writhing in mice (MNF). This release was inhibited by dipyrone (3.5-35 microng/ml) but not by indomethacin (0.5-2 microng/ml). Writhing in mice induced by the factor is blocked by dipyrone (0.5-50 mg/kg) and indomethacin (0.5-2 mg/kg). These results indicate that in addition to the previously described direct blockade of hyperalgesia by dipyrone, this drug may also affect the release of MNF, wich induces in vivo nociception through the release of prostaglandin-like substances
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Índice:
LILACS
Asunto principal:
Nociceptores
/
Dipirona
/
Indometacina
/
Macrófagos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1988
Tipo del documento:
Article
/
Congress and conference
/
Project document