Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin
Clinics
; 66(11): 1949-1954, 2011. ilus
Article
en En
| LILACS
| ID: lil-605877
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVE:
After burn injuries, scarred skin lacks elasticity, especially in hypertrophic scars. Topical treatment with tretinoin can improve the appearance and quality of the skin (i.e., texture, distensibility, color, and hydration). The objective of this prospective study was to examine the effects of treatment with 0.05 percent tretinoin for one year on the biomechanical behavior and histological changes undergone by facial skin with post-burn scarring.Setting:
Tertiary, Institutional.METHOD:
Fifteen female patients who had suffered partial thickness burns with more than two years of evolution were selected. Skin biopsies were obtained initially and after one year of treatment. The resistance and elastance of these skin biopsies were measured using a mechanical oscillation analysis system. The density of collagen fibers, elastic fibers, and versican were determined using immunohistochemical analysis.RESULTS:
Tretinoin treatment significantly lowered skin resistance and elastance, which is a result that indicates higher distensibility of the skin. However, tretinoin treatment did not significantly affect the density of collagen fibers, elastic fibers, or versican.CONCLUSION:
Topical tretinoin treatment alters the mechanical behavior of post-burn scarred skin by improving its distensibility and thus leads to improved quality of life for patients.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Tretinoina
/
Quemaduras
/
Cicatriz Hipertrófica
/
Elasticidad
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Traumatismos Faciales
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Queratolíticos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
Idioma:
En
Revista:
Clinics
Asunto de la revista:
MEDICINA
Año:
2011
Tipo del documento:
Article