Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Genet. mol. biol
;
34(4): 539-545, 2011. tab
Artículo
en Inglés
| LILACS
| ID: lil-605936
ABSTRACT
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Polimorfismo Genético
/
Características de la Población
/
Sistema del Grupo Sanguíneo ABO
/
Haplotipos
/
Brasil
/
Receptores de Complemento 3b
/
Ecosistema Amazónico
/
Malaria
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2011
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Hemocentro do Amazonas/BR
/
Iowa State University/US
/
Santa Casa de São Paulo/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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