The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
106(8): 1055-1057, Dec. 2011. ilus, graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-610987
ABSTRACT
In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-Iβ-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain increased the trypanocidal activity while maintaining its cytotoxicity. The selective index shows that MTZ-I was 10 times more active against T. cruzi than it was against mammalian cells. The modification of MTZ side chains provides a promising avenue for the development of new drugs.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Tripanocidas
/
Trypanosoma cruzi
/
Beta-Ciclodextrinas
/
Metronidazol
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2011
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto de Pesquisas René Rachou-Fiocruz/BR
/
Universidade Federal de Minas Gerais/BR
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