Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: un estudio preliminar / CRF-BP and SLC6A4 gene polymorphisms among restrained eaters
Rev. méd. Chile
;
139(10): 1261-1268, oct. 2011. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-612192
ABSTRACT
Background:
Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.Aim:
To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material andMethods:
The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.Results:
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.Conclusions:
The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Polimorfismo Genético
/
Proteínas Portadoras
/
Trastornos de Alimentación y de la Ingestión de Alimentos
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
/
Frecuencia de los Genes
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adolescente
/
Femenino
/
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2011
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Concepción/CL
/
Universidad de La Frontera/CL
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