Gram-negative osteomyelitis: clinical and microbiological profile
Braz. j. infect. dis
;
16(1): 63-67, Jan.-Feb. 2012. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-614552
ABSTRACT
INTRODUCTION:
Despite the growing interest in the study of Gram-negative bacilli (GNB) infections, very little information on osteomyelitis caused by GNB is available in the medical literature. OBJECTIVES ANDMETHODS:
To assess clinical and microbiological features of 101 cases of osteomyelitis caused by GNB alone, between January 2007 and January 2009, in a reference center for the treatment of high complexity traumas in the city of São Paulo.RESULTS:
Most patients were men (63 percent), with median age of 42 years, affected by chronic osteomyelitis (43 percent) or acute osteomyelitis associated to open fractures (32 percent), the majority on the lower limbs (71 percent). The patients were treated with antibiotics as inpatients for 40 days (median) and for 99 days (median) in outpatient settings. After 6 months follow-up, the clinical remission rate was around 60 percent, relapse 19 percent, amputation 7 percent, and death 5 percent. Nine percent of cases were lost to follow-up. A total of 121 GNB was isolated from 101 clinical samples. The most frequently isolated pathogens were Enterobacter sp. (25 percent), Acinetobacter baumannii (21 percent) e Pseudomonas aeruginosa (20 percent). Susceptibility to carbapenems was about 100 percent for Enterobacter sp., 75 percent for Pseudomonas aeruginosa and 60 percent for Acinetobacter baumannii.CONCLUSION:
Osteomyelitis caused by GNB remains a serious therapeutic challenge, especially when associated to nonfermenting bacteria. We emphasize the need to consider these agents in diagnosed cases of osteomyelitis, so that an ideal antimicrobial treatment can be administered since the very beginning of the therapy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Osteomielitis
/
Bacterias Gramnegativas
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
/
Recién Nacido
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS