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Characterization of virulence genes cagA and vacA in Helicobacter Pylori and their prevalence in gastrointestinal disorders
Cogo, Laura Lúcia; Monteiro, Cristina Leise Bastos; Nogueira, Keite da Silva; Palmeiro, Jussara Kasuko; Ribeiro, Marcelo Lima; Camargo, Eloá Ramalho de; Neves, Daniel Locatelli; Nascimento, Aguinaldo José do; Costa, Libera Maria Dalla.
  • Cogo, Laura Lúcia; Universidade Federal do Paraná. Curitiba. BR
  • Monteiro, Cristina Leise Bastos; Universidade Federal do Paraná. Curitiba. BR
  • Nogueira, Keite da Silva; Universidade Federal do Paraná. Curitiba. BR
  • Palmeiro, Jussara Kasuko; Universidade Federal do Paraná. Curitiba. BR
  • Ribeiro, Marcelo Lima; Universidade São Francisco. Bragança Paulista. BR
  • Camargo, Eloá Ramalho de; Universidade São Francisco. Bragança Paulista. BR
  • Neves, Daniel Locatelli; s.af
  • Nascimento, Aguinaldo José do; Universidade Federal do Paraná. Curitiba. BR
  • Costa, Libera Maria Dalla; Universidade Federal do Paraná. Curitiba. BR
Braz. j. microbiol ; 42(4): 1289-1295, Oct.-Dec. 2011. tab
Artículo en Inglés | LILACS | ID: lil-614586
ABSTRACT
Prevalence of H. pylori infection was determined using cultures of gastric biopsy samples of patients attended at the academic hospital of the Federal University of Paraná, Curitiba, Paraná, Brazil. Molecular methods were used to characterize the cagA and vacA genes from bacterial isolates associated with different diseases presented by patients. Out of a total of 81, forty-two gastric biopsy samples tested were positive for H. pylori, with a prevalence of 51.9 percent. No significant difference was found with regard to the gender (p=0.793) and age (p=0.183) of the patients. Genotype s1m1 vacA gene was found in 67 percent of the cases of peptic ulcer investigated (p=1.0), despite the limited number of patients with this disease (n=3). A correlation between the presence of less virulent strains (s2m2) and reflux esophagitis was found in the majority of the cases (45 percent), but without statistical significance. An association between the prevalence of cagA gene, found in 92 percent of isolates, and peptic ulcer was not observed (p=1.0), suggesting that this gene cannot be considered a specific marker of severity in our environment. The results reinforce the importance of conducting regional studies and the need to characterize H. pylori virulence genes associated with different diseases.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Úlcera Péptica / Úlcera Gástrica / Biopsia / Esofagitis Péptica / Helicobacter pylori / Infecciones por Helicobacter / Técnicas y Procedimientos Diagnósticos Tipo de estudio: Estudio diagnóstico / Estudio de prevalencia / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Braz. j. microbiol Asunto de la revista: Microbiologia Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Paraná/BR / Universidade São Francisco/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Úlcera Péptica / Úlcera Gástrica / Biopsia / Esofagitis Péptica / Helicobacter pylori / Infecciones por Helicobacter / Técnicas y Procedimientos Diagnósticos Tipo de estudio: Estudio diagnóstico / Estudio de prevalencia / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Braz. j. microbiol Asunto de la revista: Microbiologia Año: 2011 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Paraná/BR / Universidade São Francisco/BR