Fertility in female survivors of Hodgkin's lymphoma
Rev. bras. hematol. hemoter
;
34(1): 48-53, 2012. tab
Artículo
en Inglés
| LILACS
| ID: lil-618303
ABSTRACT
Currently, Hodgkin's lymphoma is one of the most curable types of cancer. Patients are often young and so the long-term morbidities of treatment have become of increasing concern. Among these, infertility is one of the most challenging consequences for patients in reproductive age. Premature ovarian failure in premenopausal women is a serious long-term sequel of the toxicity of chemotherapy. The main consequence of this syndrome is infertility, but women also present other symptoms related to estrogen deprivation. Different rates of impaired gonadal function are reported, depending on the patient's age, stage of disease, dose and intensity of chemotherapy and the use of radiation therapy. The most established strategy in female infertility is cryopreservation of embryos after in vitro fertilization. Additionally, the use of oral contraceptives or gonadotropinreleasing hormone analogs (GnRH-a) during treatment is under study. This review will provide a general overview of the main studies conducted to evaluate the infertility rate among female Hodgkin's lymphoma survivors and risk factors associated to treatment, different end-point definitions for evaluating fertility and also a brief description of the available strategies for fertility preservation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Hodgkin
/
Sobrevivientes
/
Fertilidad
Tipo de estudio:
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Italia
Institución/País de afiliación:
L'Università di Modena e Reggio Emilia/IT
/
Ospedale Civile Santo Spirito/IT
/
Universidade Federal do Rio de Janeiro/BR
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