Gliomas de alto grado en adultos / High grade gliomas in adults

ABSTRACT

Malignant gliomas represent 80 percent of primary malignant central nervous system tumors. It generally presents with headache, epilepsy, cognitive change, dysphasia, or progressive hemiparesia. Current standard treatment for malignant glioma includes surgical resection or biopsy, radiation therapy and/or chemotherapy. The prognosis of malignant gliomas is still dismal despite aggressive treatment attempts. Understanding the molecular pathogenesis of glioma may lead to a rational development of new therapies. This review summarizes the diagnosis and management of these tumors in adults.