Asociación inversa entre enfermedad de Alzheimer y cáncer / Inverse relationship between Alzheimer's disease and cancer
Rev. Hosp. Clin. Univ. Chile
;
20(3): 199-206, 2009. tab
Artículo
en Español
| LILACS
| ID: lil-620964
ABSTRACT
The increase in life expectancy is accompanied by a concomitant increase in the prevalence of age related disorders, including neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, and various types of cancers. We here report epidemiologic findings suggesting thatthe development of the Alzheimer and a history of cancer are inversely related. The inverse relationship was found when all cancer types were analyzed and also when skin cancers (bothmelanomas and those with good prognosis, that constitute 50% of all cancers) were analyzed separately. In addition, in a population study we found that this inverse relationship was found with dementia of the Alzheimer type and mixed dementia, but not with vascular dementia, suggesting that the association is only with degenerative diseases. We discuss possible explanations for this inverse relationship, among them, the possibility that a common biological mechanism might be regulated in opposite directions in neurodegenerative diseases and cancer.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Alzheimer
/
Neoplasias
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. Hosp. Clin. Univ. Chile
Asunto de la revista:
Medicina
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Clínico de la Universidad de Chile/CL
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