Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento / Effects of semicarbazide on skeleton of growing Wistar rats
Arq. bras. med. vet. zootec
;
64(2): 499-504, abr. 2012. ilus, tab
Artículo
en Portugués
| LILACS
| ID: lil-622508
ABSTRACT
The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Idioma:
Portugués
Revista:
Arq. bras. med. vet. zootec
Asunto de la revista:
Medicina Veterinaria
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Portugal
Institución/País de afiliación:
Universidade Lusófona de Humanidades e Tecnologias/PT
/
Universidade de Coimbra/PT
/
Universidade de Évora/PT
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