Increasing antibiotic resistance among uropathogens isolated during years 2006-2009: impact on the empirical management
Int. braz. j. urol
;
38(1): 25-32, Jan.-Feb. 2012. graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-623311
ABSTRACT
Urinary tract infections (UTI) are one of the most common infections with an increasing resistance to antimicrobial agents. PURPOSE:
Empirical initial antibiotic treatment of UTI must rely on susceptible data from local studies. MATERIALS ANDMETHODS:
Retrospective analysis of isolated bacteria from children with UTIs was performed at the university hospital during years 2006-2009. The findings were compared with data collected in a similar study carried out in 2002- 2003.RESULTS:
A total of 1439 uropathogens were isolated. Escherichia coli (E.coli) was the leading cause, followed by Enterobacter, and other gram negative bacilli. It was observed resistance of E.coli to ceftriaxone, cefexime, amikacin, gentamycin, and nalidixic acid; Enterobacter to cefexime; and the resistance of gram negative bacilli to gentamicin and cefexime increased significantly. The highest effective antibiotic was Imipenem, ciprofloxacin, and amikacin with 96.7%, 95% and 91% sensitivity rates , respectively, followed by ceftriaxone 77.2%, gentamicin 77%, nitrofurantoin 76.4%, nalidixic acid 74.3% and cefexime with 70%.CONCLUSION:
The use of nitrofurantoin or nalidixic acid as initial empirical antibacterial therapy for cystitis seems appropriate. For cases of simple febrile UTI, the use of initial parenteral therapies with amikacin or ceftriaxone followed by an oral third generation cephalosporin also seemed appropriated, and in cases of severely ill patients or complicated UTI, imipenem as monotherapy or, a combination of Ceftriaxone with an aminoglycoside, are recommended.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones Bacterianas
/
Infecciones Urinarias
/
Farmacorresistencia Bacteriana Múltiple
/
Antibacterianos
Tipo de estudio:
Estudio observacional
Límite:
Niño
/
Child, preschool
/
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2012
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Tehran University of Medical Sciences/IR
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